Volume : 3, Issue : 3, JUN 2019

Green Coffee Beans as a Weight Loss Supplement

Ashwani, Deepika, Dr. Bharat Prashar


More than one third of the United States is considered obese, according to the Centres for Disease Control. [1] Obesity is known to contribute to comorbid conditions such as diabetes, hypertension, dyslipidaemia, respiratory problems, and many other diseases, all of which may become life threatening. Patients are classified as obese if their body mass index is greater than or equal to 30 kg/m2 and overweight if their body mass index is between 25 and 29.9 kg/m2[2] Since 1960, there has been a dramatic increase in the portion of the population classified as overweight or obese [3] Evidence is accumulating from animal studies regarding the use of GCE as a weight loss supplement [34]. In human subjects, coffee intake has been reported to be inversely associated with weight gain [5]. Consumption of coffee has also been shown to produce changes in several glycaemic markers in older adults [6]. Similarly, different analysis has indicated that the consumption of caffeinated coffee cause some reductions in long-run weight gain, an effect which is likely to be due to the known thermogenic effects of caffeine intake as well as effects of GCE and other pharmacologically active substances present in coffee [7]. GCE has also been postulated to modify hormone secretion and glucose tolerance in humans [8]. This effect is accomplished by facilitating the absorption of glucose from the distal, rather than the proximal part of the gastrointestinal tract.


The objective of this paper is to analyse the results of human clinical trials assessing the effectivity of GCE as a weight-reducing agent.


Obesity, weight loss, green coffee extract, chlorogenic acid.

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  1. Centers for Disease Control and Prevention. Overweight and obesity. http://www.cdc.gov/obesity. Accessed October 26, 2012.


  1. S. Department of Health and Human Services. Body mass index. http://nhlbisupport.com/bmi. Accessed October 26, 2012.


  1. National Institutes of Health. Clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: the evidence report. Obes Res. 1998;6(suppl 2):51S-209S


  1. Shimoda H, Seki E, Aitani M. Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complementary and Alternative Medicine. 2006;6, article 9[PMC free article] [PubMed] [Google Scholar]


  1. Cho A-S, Jeon S-M, Kim M-J, et al. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food and Chemical Toxicology. 2010;48(3):937–943.[PubMed] [Google Scholar]


  1. Lopez-Garcia E, Van Dam RM, Rajpathak S, Willett WC, Manson JE, Hu FB. Changes in caffeine intake and long-term weight change in men and women. American Journal of Clinical Nutrition. 2006;83(3):674–680.[PubMed] [Google Scholar]


  1. Hiltunen LA. Are there associations between coffee consumption and glucose tolerance in elderly subjects? European Journal of Clinical Nutrition. 2006;60(10):1222-1225. [PubMed][Google Scholar]


  1. Greenberg JA, Boozer CN, Geliebter A. Coffee, diabetes, and weight control. American Journal of Clinical Nutrition. 2006;84(4):682-693. [PubMed] [Google Scholar]
  2. Johnston KL, Clifford MN, Morgan LM. Coffee acutely modifies gastrointestinal hormone secretion and glucose tolerance in humans: glycemic effects of chlorogenic acid and caffeine. American Journal of Clinical Nutrition. 2003; 78(4):728–733. [PubMed] [Google Scholar]


  1. Dunn D (2015) Addressing the Problem of Obesity. AORN J 102: 111-115.


  1. Mohammadshahi M, Haidari F, Karandish M, Ebrahimi S, Haghighizadeh MH (2014) A Randomized Clinical Trial of Nutrition Education for improvement of Diet Quality and Inflammation in Iranian Obese Women. J Nutr Metab 605782.


  1. Haidari F, Shirbeigi E, MakanCheraghpour, Mohammadshahi M (2014) Association of dietary patterns with body mass index, waist circumference, and blood pressure in an adult population in Ahvaz, Iran. Saudi Med J 35: 967-974.


  1. Finucane MM, Stevens GA, Cowan MJ, Danaei G, Lin JK, et al. (2011) National, regional, and global trends in body-mass index since 1980: systematic analysis of health examination surveys and epidemiological studies with 960 countryyears and 9.1 million participants. Lancet 377: 557-567.


  1. Salem Z, Rezaeian M (2011) Interventional drug therapy. Zahedan J Res Med Sci 10: 41-57.


  1. Ormsbee MJ, Rawal SR, Baur DA, Kinsey AW, Elam ML, et al. (2014) The effects of a multi-ingredient dietary supplement on body composition, adipokines, blood lipids, and metabolic health in overweight and obese men and women: a randomized controlled trial. J Int Soc Sports Nutr 11: 37-47.


  1. Tverdal A, Skurtveit S (2003) Coffee intake and mortality from liver cirrhosis. Ann Epidemiol 13: 419-423.


  1. Van Dam RM, Hu FB (2005) Coffee consumption and risk of type 2 diabetes: a systematic review. JAMA 294: 97-104.


  1. Greenberg JA, Boozer CN, Geliebter A (2006) Coffee, diabetes, and weight Am J Clin Nutr 84: 682-693.


  1. Tanaka K, Shoko N, Shizuka T, Mihoko K, Hiroshi S, et al. (2009) Anti-obesity and hypotriglyceridemic properties of coffee bean extract in SD rats. Food Sci Technol Res 15: 147-152.


  1. MuraseT, Misawa K, Minegishi Y, Aoki M, Ominami H, et al. (2011) Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1c and related molecules in C57BL/6J mice. Am J Physiol Endocrinol Metab 300: 122-133.


  1. Ho L, Varghese M, Wang J, Zhao W, Chen F, et al. (2012) Dietary supplementation with decaffeinated green coffee improves diet-induced insulin resistance and brain energy metabolism in mice. Nutr Neuroscience 15: 37-45.


  1. Higdon JV, Frei B (2006) Coffee and health: a review of recent human research. Crit Rev Food Sci Nutr 46: 101-123.


  1. Inoue M, Kurahashi N, Iwasaki M, Shimazu T, Tanaka Y (2009) Effect of coffee and green tea consumption on the risk of liver cancer: cohort analysis by hepatitis virus infection status. Cancer Epidemiol Biomarkers Prev 18: 1746


  1. Andrade KS, Goncalvez RT, Maraschin M, Ribeiro-do-Valle RM, Martinez J, et al. (2012) Supercritical fluid extraction from spent coffee grounds and coffee husks: antioxidant activity and effect of operational variables on extract Talanta 88: 544-552.


  1. Watanabe T, Arai Y, Mitsui Y, Kusaura T, Okawa W, et al. (2006) The blood


  1. Song SJ, Choi S, Park T (2014) Decaffeinated Green Coffee Bean Extract Attenuates Diet-Induced Obesity and Insulin Resistance in Mice. Evid Based Complement Alternat Med 2014: 718379.


  1. Friedman M (1997) Chemistry, Biochemistry, and Dietary Role of Potato A Review. J Agric Food Chem 45: 1523-1540.


  1. Devanand L, Mukhopadhyay L, Mukhopadhyay S (2006) Influence of Sample Preparation on Assay of Phenolic Acids from Eggplant. J Agric Food Chem 54: 41-47.


  1. Stacewicz-Sapuntzakis M, Bowen PE, Hussain EA, Damayanti-Wood BI, Farnsworth NR (2001) Chemical composition and potential health effects of prunes: a functional food? Crit Rev Food Sci Nutr 41: 251-286.


  1. MuraseT, Misawa K, Minegishi Y, Aoki M, Ominami H, et al. (2011) Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1c and related molecules in C57BL/6J mice. Am J Physiol Endocrinol Metab 300: 122-133.


  1. Shimoda H, Seki E, Aitani M (2006) Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice. BMC Complement Altern Med 6: 9-15.


  1. Vinson J, Burnham B, Nagendran MV (2012) Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects. Diabetes Metab Syndr Obes 5: 21-27.


  1. Meng S, Cao J, Feng Q, Peng J, Hu Y (2013) Roles of Chlorogenic Acid on Regulating Glucose and Lipids Metabolism: A Review. Evid Based Complement Alternat Med 2013: 801457.


  1. Henry-Vitrac C, Ibarra A, Roller M, Merillon JM, Vitrac X (2010) Contribution of chlorogenic acids to the inhibition of human hepatic glucose-6-phosphatase activity in vitro by Svetol, a standardized decaffeinated green coffee extract. J Agric Food Chem 58: 4141-4144.


  1. Farah A, Monteiro M, Donangelo CM, Lafay S (2008) Chlorogenic Acids from Green Coffee Extract are Highly Bioavailable in Humans. J Nutr 138: 2309


  1. Suzuki A, Fujii A, Jokura H, Tokimitsu I, Hase T, et al. (2008) Hydroxy hydroquinone interferes with the chlorogenic acid-induced restoration of endothelial function in spontaneously hypertensive rats. Am J Hypertens 21: 23-27.


  1. Zheng G, Qiu Y, Zhang QF, Li D (2014) Chlorogenic acid and caffeine in metabolism related